Toxicology Triaging System

  1. Suite of solutions to expedite reporting of preclinical toxicologic pathology studies in rodents.

  • Set of algorithms to separate and triage sections from different tissues in toxicology studies.
  • Pre-sorted images for triaged reporting.
  • Automated organ separation to identify organs and enable batch processing.
  • Batch analysis for faster turnaround of high throughput toxicology studies.
  • Segmentation and quantification of “Not normal” features.
  • Quantitative results with comprehensive display of annotated outputs.
  • Compliance with INHAND terminology.
  • Accelerated translation and application to additional species or tissue types.
  • Efficient workflow resulting in significant reduction in drug discovery time.

Glomerulosclerosis Quantification

  • Quantification of histomorphological parameters in efficacy models for Chronic Kidney Disease .
  • Segments glomeruli and quantifies glomerulosclerosis in Masson Trichrome stained sections from rodent kidney .
  • Reduces the time and effort expended in manual annotation of glomeruli and quantification of glomerulosclerosis .
  • Improves accuracy and reproducibility of quantification results .

Rodent Cardiomyopathy Scoring

  • Solutions for sensitive and consistent detection and quantification of Progressive Cardiomyopathy (PCM) features in rodent heart sections .
  • Objective quantification of the histomorphological features of PCM, to assist pathologists in discerning cardiotoxicity-associated changes .
  • Accurate severity scoring to help differentiate spontaneous from test article-related findings .
  • High values for accuracy, intersection over union, and dice coefficient for each individual feature .
  • Strong positive correlation with the median severity grade assigned by panel of pathologists and the percentage area of the heart predicted to have PCM lesions by the algorithm .

Hepatic steatosis quantification

  • Quantification of histomorphological parameters in NAFLD rodent models .
  • Accurate detection and quantification of fatty vacuoles in H&E stained rodent liver sections .
  • Differentiation of fatty vacuoles from lumina of blood vessels and bile ducts .
  • Strong and significant correlation (r = 0.87, p < .001) with semi-quantitative/manual assessment methods .

Pulmonary Fibrosis Grading

  • Deep learning and Image processing network to quantify morphological changes in animal models for Bleomycin induced lung fibrosis .
  • Accurate and objective segmentation and quantification of histomorphological parameters in rodent lung sections stained with Picrosirius Red and Haematoxyin & Eosin (H&E) .
  • High throughput method for quantification of fibrosis in whole slide images of rodent lung.
  • No restriction on field of analysis, negating selection bias to improve accuracy.
  • Segmentation accuracy of more than 95% across parameters with strong correlation with manual grading using modified Ashcroft’s score.

Hepatic Fibrosis Quantification

  • Accurate quantification of liver fibrosis to aid evaluation of efficacy models for novel therapies.
  • Segmentation and quantification of fibrous septa in Picrosirius stained sections of rodent liver.
  • Applicable on microscope based analysis of field of view images as well as whole slide images.
  • Strong positive correlation (p < .001) with semi-quantitative assessment by pathologists (Ishak score).

Spermatogenic staging assessment

  • Automated method to identify the stages of rat spermatogenic cycle in digital images of Hematoxylin and Eosin stained testes.
  • Negates the need for assessment of conventional PAS stained sections.
  • Aids “stage-aware” histopathological evaluation of testes to detect effects on spermatogenesis in pre-clinical toxicology studies.
  • Uses multiple criteria, based largely on the shape and movement of the elongating spermatids within the seminiferous tubule.
  • Identifies spermatogenic stage of each tubule, allowing the pathologist to quickly evaluate the testis in a stage aware manner with rapid calculation of the stage frequencies.
  • WSI staged in minutes as opposed to several days for manual staging; with objective, quantitative and reproducible outputs.
  • Very good agreement for all the stages with Precision, Recall, and F1-score of 0.93 and 0.96 and 0.94 respectively, and overall accuracy of the staging analysis of 0.98.

Estrous Staging Assessment

  • Deep Learning and Image Processing solution for automated Estrous staging in rodents.
  • Algorithms for evaluation of rodent vaginal and uterine sections, to aid stage aware assessment of female reproductive tissues.
  • Segments and quantifies different histological layers, cellular changes and inflammatory cells.
  • Sensitivity and Specificity range from 88% to 97% across stages (vaginal sections).
NOTE: Unless otherwise stated, all products are “Research Use Only”; not for use in diagnostic procedures.

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